The Social Benefits of Expedited Risk Assessments

@article{citeulike:1108241, abstract = {The present regulation of carcinogens is quite slow; hundreds of substances that have tested positive for carcinogenicity in animal bioassays have not been addressed by the U.S. regulatory system. This carries with it unappreciated social, economic, and public health costs. However, there are readily available expedited approximation procedures for assessing the potency of carcinogens whose use has substantial benefits that outweigh any costs from less science-intensive and less extensively documented assessments. These benefits can be seen by using a model to suggest the magnitude of social costs in regulating carcinogens by current conventional methods compared with expedited procedures for assessing the potency of known carcinogens. Two scenarios, one in accordance with current agency presumptions and one which assumes extreme unreliability in animal data and in the accuracy of potency assessments, compare conventional science-intensive and expedited procedures. On both, the total social costs of expedited procedures are lower than conventional procedures across a wide range of values assigned for individual mistakes of under regulation and over regulation. It appears better to evaluate a larger universe of known carcinogens somewhat less intensively for each substance than to evaluate a small proportion of that same universe very carefully and delay considering the rest.}, author = {Cranor, Carl F. }, citeulike-article-id = {1108241}, doi = {10.1111/j.1539-6924.1995.tb00328.x}, journal = {Risk Analysis}, keywords = {regulation, risk\_assessment}, number = {3}, pages = {353--358}, posted-at = {2007-02-15 09:56:51}, priority = {2}, title = {The Social Benefits of Expedited Risk Assessments}, url = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1539-6924.1995.tb00328.x}, volume = {15}, year = {1995} }

TY - JOUR ID - citeulike:1108241 L3 - citeulike-article-id:1108241 TI - The Social Benefits of Expedited Risk Assessments JF - Risk Analysis VL - 15 IS - 3 SP - 353 EP - 358 N2 - The present regulation of carcinogens is quite slow; hundreds of substances that have tested positive for carcinogenicity in animal bioassays have not been addressed by the U.S. regulatory system. This carries with it unappreciated social, economic, and public health costs. However, there are readily available expedited approximation procedures for assessing the potency of carcinogens whose use has substantial benefits that outweigh any costs from less science-intensive and less extensively documented assessments. These benefits can be seen by using a model to suggest the magnitude of social costs in regulating carcinogens by current conventional methods compared with expedited procedures for assessing the potency of known carcinogens. Two scenarios, one in accordance with current agency presumptions and one which assumes extreme unreliability in animal data and in the accuracy of potency assessments, compare conventional science-intensive and expedited procedures. On both, the total social costs of expedited procedures are lower than conventional procedures across a wide range of values assigned for individual mistakes of under regulation and over regulation. It appears better to evaluate a larger universe of known carcinogens somewhat less intensively for each substance than to evaluate a small proportion of that same universe very carefully and delay considering the rest. KW - regulation KW - risk_assessment AU - Cranor, Carl PY - 1995/// UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1539-6924.1995.tb00328.x ER -