Two-Stage Selection and Testing Designs for Comparative Clinical Trials

@article{citeulike:2478904, abstract = {A two-stage design which selects the best of several experimental treatments and compares it to a standard control is proposed. The design allows early termination with acceptance of the global null hypothesis. Optimal sample size and cut-off parameters are obtained by minimizing expected total sample size for fixed significance level and power.}, author = {Thall, Peter F. and Simon, Richard and Ellenberg, Susan S. }, citeulike-article-id = {2478904}, journal = {Biometrika}, keywords = {clinical\_trial, selection\_design}, number = {2}, pages = {303--310}, posted-at = {2008-03-06 14:16:33}, priority = {2}, title = {Two-Stage Selection and Testing Designs for Comparative Clinical Trials}, url = {http://www.jstor.org/stable/2336178}, volume = {75}, year = {1988} }

TY - JOUR ID - citeulike:2478904 L3 - citeulike-article-id:2478904 TI - Two-Stage Selection and Testing Designs for Comparative Clinical Trials JF - Biometrika VL - 75 IS - 2 SP - 303 EP - 310 N2 - A two-stage design which selects the best of several experimental treatments and compares it to a standard control is proposed. The design allows early termination with acceptance of the global null hypothesis. Optimal sample size and cut-off parameters are obtained by minimizing expected total sample size for fixed significance level and power. KW - clinical_trial KW - selection_design AU - Thall, Peter AU - Simon, Richard AU - Ellenberg, Susan PY - 1988/// UR - http://www.jstor.org/stable/2336178 ER -