C-Reactive Protein, Inflammatory Conditions, and Cardiovascular Disease Risk

@article{citeulike:2393101, abstract = {Background It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community.Methods We evaluated 3782 Framingham Offspring Study participants (mean age 55 years; 52\% women) free of baseline cardiovascular disease. Logistic regression models examined the prevalence of common inflammatory conditions by CRP categories, while a separate matched case-referent analysis evaluated the prevalence of uncommon inflammatory conditions. Cox models were used to assess the influence of common inflammatory conditions on relations between CRP and incident cardiovascular disease.Results Common inflammatory conditions were reported by nearly half of the participants; these individuals were more likely to have markedly high CRP concentrations (>10 mg/L, P for trend = .001). In multivariable models, there were increased odds of having at least one common inflammatory condition with CRP concentrations of 1-3.0, 3.01-10, and >10 mg/L, compared with the referent category (<1 mg/L); the respective odds ratios with 95\% confidence intervals were 1.41 (1.07-1.86), 1.45 (1.07-1.98), and 1.64 (1.09-2.47) in men, and 1.08 (0.82-1.43), 1.07 (0.80-1.44), and 1.38 (0.97-1.96) in women. In case-referent analyses, uncommon inflammatory conditions were more common in individuals with CRP >10 mg/L compared with those with CRP <1 mg/L (12.1\% vs 6.6\%; P = .0001). In multivariable models, higher CRP categories were not associated with incident cardiovascular disease, and with additional adjustment for inflammatory conditions, results remained unchanged.Conclusion There is high prevalence of common and uncommon inflammatory conditions in individuals with high CRP concentrations. Higher CRP concentrations should be interpreted with caution in cardiovascular disease risk assessment.}, author = {Dhingra, Ravi and Gona, Philimon and Nam, Byung-Ho and D'Agostino and Wilson, Peter W. and Benjamin, Emelia J. and O'Donnell, Christopher J. }, citeulike-article-id = {2393101}, doi = {10.1016/j.amjmed.2007.08.037}, journal = {The American Journal of Medicine}, keywords = {cardiovascular, disease, inflammatory, protein, risk}, month = {December}, number = {12}, pages = {1054--1062}, posted-at = {2008-02-18 09:29:45}, priority = {2}, title = {C-Reactive Protein, Inflammatory Conditions, and Cardiovascular Disease Risk}, url = {http://dx.doi.org/10.1016/j.amjmed.2007.08.037}, volume = {120}, year = {2007} }

TY - JOUR ID - citeulike:2393101 L3 - citeulike-article-id:2393101 TI - C-Reactive Protein, Inflammatory Conditions, and Cardiovascular Disease Risk JF - The American Journal of Medicine VL - 120 IS - 12 SP - 1054 EP - 1062 N2 - Background It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community.Methods We evaluated 3782 Framingham Offspring Study participants (mean age 55 years; 52% women) free of baseline cardiovascular disease. Logistic regression models examined the prevalence of common inflammatory conditions by CRP categories, while a separate matched case-referent analysis evaluated the prevalence of uncommon inflammatory conditions. Cox models were used to assess the influence of common inflammatory conditions on relations between CRP and incident cardiovascular disease.Results Common inflammatory conditions were reported by nearly half of the participants; these individuals were more likely to have markedly high CRP concentrations (>10 mg/L, P for trend = .001). In multivariable models, there were increased odds of having at least one common inflammatory condition with CRP concentrations of 1-3.0, 3.01-10, and >10 mg/L, compared with the referent category (<1 mg/L); the respective odds ratios with 95% confidence intervals were 1.41 (1.07-1.86), 1.45 (1.07-1.98), and 1.64 (1.09-2.47) in men, and 1.08 (0.82-1.43), 1.07 (0.80-1.44), and 1.38 (0.97-1.96) in women. In case-referent analyses, uncommon inflammatory conditions were more common in individuals with CRP >10 mg/L compared with those with CRP <1 mg/L (12.1% vs 6.6%; P = .0001). In multivariable models, higher CRP categories were not associated with incident cardiovascular disease, and with additional adjustment for inflammatory conditions, results remained unchanged.Conclusion There is high prevalence of common and uncommon inflammatory conditions in individuals with high CRP concentrations. Higher CRP concentrations should be interpreted with caution in cardiovascular disease risk assessment. KW - cardiovascular KW - disease KW - inflammatory KW - protein KW - risk AU - Dhingra, Ravi AU - Gona, Philimon AU - Nam, Byung-Ho AU - D'Agostino AU - Wilson, Peter AU - Benjamin, Emelia AU - O'Donnell, Christopher PY - 2007/12// UR - http://dx.doi.org/10.1016/j.amjmed.2007.08.037 ER -