From Genotype to Phenotype: Systems Biology Meets Natural Variation

by: Philip N Benfey, Thomas Mitchell-Olds

Science, Vol. 320, No. 5875. (25 April 2008), pp. 495-497.

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Abstract

The promise that came with genome sequencing was that we would soon know what genes do, particularly genes involved in human diseases and those of importance to agriculture. We now have the full genomic sequence of human, chimpanzee, mouse, chicken, dog, worm, fly, rice, and cress, as well as those for a wide variety of other species, and yet we still have a lot of trouble figuring out what genes do. Mapping genes to their function is called the "genotype-to-phenotype problem," where phenotype is whatever is changed in the organism when a gene's function is altered. 10.1126/science.1153716

@article{citeulike:2714469, abstract = {The promise that came with genome sequencing was that we would soon know what genes do, particularly genes involved in human diseases and those of importance to agriculture. We now have the full genomic sequence of human, chimpanzee, mouse, chicken, dog, worm, fly, rice, and cress, as well as those for a wide variety of other species, and yet we still have a lot of trouble figuring out what genes do. Mapping genes to their function is called the "genotype-to-phenotype problem," where phenotype is whatever is changed in the organism when a gene's function is altered. 10.1126/science.1153716}, author = {Benfey, Philip N. and Mitchell-Olds, Thomas }, citeulike-article-id = {2714469}, doi = {10.1126/science.1153716}, journal = {Science}, keywords = {function, gene, genotype, mapping, phenotype}, month = {April}, number = {5875}, pages = {495--497}, posted-at = {2008-04-29 13:08:50}, priority = {2}, title = {From Genotype to Phenotype: Systems Biology Meets Natural Variation}, url = {http://dx.doi.org/10.1126/science.1153716}, volume = {320}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2714469 L3 - citeulike-article-id:2714469 TI - From Genotype to Phenotype: Systems Biology Meets Natural Variation JF - Science VL - 320 IS - 5875 SP - 495 EP - 497 N2 - The promise that came with genome sequencing was that we would soon know what genes do, particularly genes involved in human diseases and those of importance to agriculture. We now have the full genomic sequence of human, chimpanzee, mouse, chicken, dog, worm, fly, rice, and cress, as well as those for a wide variety of other species, and yet we still have a lot of trouble figuring out what genes do. Mapping genes to their function is called the "genotype-to-phenotype problem," where phenotype is whatever is changed in the organism when a gene's function is altered. 10.1126/science.1153716 KW - function KW - gene KW - genotype KW - mapping KW - phenotype AU - Benfey, Philip AU - Mitchell-Olds, Thomas PY - 2008/04/25/ UR - http://dx.doi.org/10.1126/science.1153716 ER -

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