Dynamics of Prefrontal and Cingulate Activity during a Reward-Based Logical Deduction Task.

@article{citeulike:1181612, abstract = {We used behavioral and functional magnetic resonance imaging (fMRI) methods to probe the cerebral organization of a simple logical deduction process. Subjects were engaged in a motor trial-and-error learning task, in which they had to infer the identity of an unknown 4-key code. The design of the task allowed subjects to base their inferences not only on the feedback they received but also on the internal deductions that it afforded (autoevaluation). fMRI analysis revealed a large bilateral parietal, prefrontal, cingulate, and striatal network that activated suddenly during search periods and collapsed during ensuing periods of sequence repetition. Fine-grained analyses of the temporal dynamics of this search network indicated that it operates according to near-optimal rules that include 1) computation of the difference between expected and obtained rewards and 2) anticipatory deductions that predate the actual reception of positive reward. In summary, the dynamics of effortful mental deduction can be tracked with fMRI and relate to a distributed network engaging prefrontal cortex and its interconnected cortical and subcortical regions.}, address = {Institut National de la Sant\'{e} et de la Recherche M\'{e}dicale 562, Cognitive Neuroimaging, Service Hospitalier Fr\'{e}d\'{e}ric Joliot, Commissariat \`{a} l'Energie Atomique/D\'{e}partement de Recherche M\'{e}dicale/Direction des Sciences du Vivant, 91401 Orsay Cedex, France.}, author = {Landmann, C. and Dehaene, S. and Pappata, S. and Jobert, A. and Bottlaender, M. and Roumenov, D. and Le Bihan, D. }, citeulike-article-id = {1181612}, issn = {1047-3211}, journal = {Cereb Cortex}, keywords = {analysis, fmri, pfc, thinking}, month = {April}, number = {4}, pages = {749--759}, posted-at = {2007-03-23 12:22:52}, priority = {2}, title = {Dynamics of Prefrontal and Cingulate Activity during a Reward-Based Logical Deduction Task.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16707739}, volume = {17}, year = {2007} }

TY - JOUR ID - citeulike:1181612 L3 - citeulike-article-id:1181612 TI - Dynamics of Prefrontal and Cingulate Activity during a Reward-Based Logical Deduction Task. JF - Cereb Cortex VL - 17 IS - 4 SP - 749 EP - 759 AD - Institut National de la Santé et de la Recherche Médicale 562, Cognitive Neuroimaging, Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique/Département de Recherche Médicale/Direction des Sciences du Vivant, 91401 Orsay Cedex, France. SN - 1047-3211 N2 - We used behavioral and functional magnetic resonance imaging (fMRI) methods to probe the cerebral organization of a simple logical deduction process. Subjects were engaged in a motor trial-and-error learning task, in which they had to infer the identity of an unknown 4-key code. The design of the task allowed subjects to base their inferences not only on the feedback they received but also on the internal deductions that it afforded (autoevaluation). fMRI analysis revealed a large bilateral parietal, prefrontal, cingulate, and striatal network that activated suddenly during search periods and collapsed during ensuing periods of sequence repetition. Fine-grained analyses of the temporal dynamics of this search network indicated that it operates according to near-optimal rules that include 1) computation of the difference between expected and obtained rewards and 2) anticipatory deductions that predate the actual reception of positive reward. In summary, the dynamics of effortful mental deduction can be tracked with fMRI and relate to a distributed network engaging prefrontal cortex and its interconnected cortical and subcortical regions. KW - analysis KW - fmri KW - pfc KW - thinking AU - Landmann, C AU - Dehaene, S AU - Pappata, S AU - Jobert, A AU - Bottlaender, M AU - Roumenov, D AU - Le Bihan, D PY - 2007/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/16707739 ER -