Noise in Gene Expression: Origins, Consequences, and Control

by: Jonathan M Raser, Erin K O'Shea

Science, Vol. 309, No. 5743. (23 September 2005), pp. 2010-2013.

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Abstract

Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression.

@article{citeulike:331186, abstract = {Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression.}, author = {Raser, Jonathan M. and O'Shea, Erin K. }, citeulike-article-id = {331186}, doi = {10.1126/science.1105891}, journal = {Science}, keywords = {clone, expression, gene, noise, stochastic}, month = {September}, number = {5743}, pages = {2010--2013}, posted-at = {2006-05-08 20:52:09}, priority = {4}, title = {Noise in Gene Expression: Origins, Consequences, and Control}, url = {http://dx.doi.org/10.1126/science.1105891}, volume = {309}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:331186 L3 - citeulike-article-id:331186 TI - Noise in Gene Expression: Origins, Consequences, and Control JF - Science VL - 309 IS - 5743 SP - 2010 EP - 2013 N2 - Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression. KW - clone KW - expression KW - gene KW - noise KW - stochastic AU - Raser, Jonathan AU - O'Shea, Erin PY - 2005/09/23/ UR - http://dx.doi.org/10.1126/science.1105891 ER -

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