Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women

@article{citeulike:2387185, abstract = {Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p \&\#61; 2.9 \&\#215; 10\&\#8722;5 in women), with a significant gene-sex effect (p \&\#61; 1.8 \&\#215; 10\&\#8722;4). We studied rs7341475 in four additional populations, totaling 2,274 cases and 4,401 controls. A significant effect was observed only in women, replicating the initial result (p \&\#61; 2.1 \&\#215; 10\&\#8722;3 in women; p \&\#61; 4.2 \&\#215; 10\&\#8722;3 for gene-sex interaction). Based on all populations the estimated relative risk of women carrying the common genotype is 1.58 (p \&\#61; 8.8 \&\#215; 10\&\#8722;7; p \&\#61; 1.6 \&\#215; 10\&\#8722;5 for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.}, author = {Shifman, Sagiv and Johannesson, Martina and Bronstein, Michal and Chen, Sam X. and Collier, David A. and Craddock, Nicholas J. and Kendler, Kenneth S. and Li, Tao and O\&\#39;donovan, Michael and O\&\#39;neill, Anthony F. and Owen, Michael J. and Walsh, Dermot and Weinberger, Daniel R. and Sun, Cuie and Flint, Jonathan and Darvasi, Ariel }, citeulike-article-id = {2387185}, doi = {10.1371/journal.pgen.0040028}, journal = {PLoS Genetics}, keywords = {gender, gwa, schizophrenia}, month = {February}, number = {2}, pages = {e28+}, posted-at = {2008-04-17 13:13:41}, priority = {2}, title = {Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women}, url = {http://dx.doi.org/10.1371/journal.pgen.0040028}, volume = {4}, year = {2008} }

TY - JOUR ID - citeulike:2387185 L3 - citeulike-article-id:2387185 TI - Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women JF - PLoS Genetics VL - 4 IS - 2 SP - e28 N2 - Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene (p = 2.9 × 10−5 in women), with a significant gene-sex effect (p = 1.8 × 10−4). We studied rs7341475 in four additional populations, totaling 2,274 cases and 4,401 controls. A significant effect was observed only in women, replicating the initial result (p = 2.1 × 10−3 in women; p = 4.2 × 10−3 for gene-sex interaction). Based on all populations the estimated relative risk of women carrying the common genotype is 1.58 (p = 8.8 × 10−7; p = 1.6 × 10−5 for gene-sex interaction). The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease. KW - gender KW - gwa KW - schizophrenia AU - Shifman, Sagiv AU - Johannesson, Martina AU - Bronstein, Michal AU - Chen, Sam AU - Collier, David AU - Craddock, Nicholas AU - Kendler, Kenneth AU - Li, Tao AU - O'donovan, Michael AU - O'neill, Anthony AU - Owen, Michael AU - Walsh, Dermot AU - Weinberger, Daniel AU - Sun, Cuie AU - Flint, Jonathan AU - Darvasi, Ariel PY - 2008/02/01/ UR - http://dx.doi.org/10.1371/journal.pgen.0040028 ER -