From classical genetics to quantitative genetics to systems biology: modeling epistasis.

@article{citeulike:2681648, abstract = {Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different loci. We propose a framework for estimating and interpreting epistasis from a classical experiment that combines the strengths of each approach. A regression analysis step accommodates the quantitative nature of expression measurements by estimating the effect of gene deletions plus any interaction. Effects are selected by significance such that a reduced model describes each expression trait. We show how the resulting models correspond to specific hierarchical relationships between two regulator genes and a target gene. These relationships are the basic units of genetic pathways and genomic system diagrams. Our approach can be extended to analyze data from a variety of experiments, multiple loci, and multiple environments.}, address = {Bioinformatics Research Center and Program in Bioinformatics, North Carolina State University, Raleigh, North Carolina, United States of America.}, author = {Aylor, D. L. and Zeng, Z. B. }, citeulike-article-id = {2681648}, doi = {10.1371/journal.pgen.1000029}, issn = {1553-7404}, journal = {PLoS genetics}, keywords = {epistasis, modeling, quantitative\_genetics, systems}, month = {March}, number = {3}, posted-at = {2008-04-17 12:57:40}, priority = {2}, title = {From classical genetics to quantitative genetics to systems biology: modeling epistasis.}, url = {http://dx.doi.org/10.1371/journal.pgen.1000029}, volume = {4}, year = {2008} }

TY - JOUR ID - citeulike:2681648 L3 - citeulike-article-id:2681648 TI - From classical genetics to quantitative genetics to systems biology: modeling epistasis. JF - PLoS genetics VL - 4 IS - 3 AD - Bioinformatics Research Center and Program in Bioinformatics, North Carolina State University, Raleigh, North Carolina, United States of America. SN - 1553-7404 N2 - Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the interaction between alleles at different loci. We propose a framework for estimating and interpreting epistasis from a classical experiment that combines the strengths of each approach. A regression analysis step accommodates the quantitative nature of expression measurements by estimating the effect of gene deletions plus any interaction. Effects are selected by significance such that a reduced model describes each expression trait. We show how the resulting models correspond to specific hierarchical relationships between two regulator genes and a target gene. These relationships are the basic units of genetic pathways and genomic system diagrams. Our approach can be extended to analyze data from a variety of experiments, multiple loci, and multiple environments. KW - epistasis KW - modeling KW - quantitative_genetics KW - systems AU - Aylor, DL AU - Zeng, ZB PY - 2008/03// UR - http://dx.doi.org/10.1371/journal.pgen.1000029 ER -