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Blurring cis and trans in Gene Regulation

by: Fabio Savarese, Rudolf Grosschedl
Cell, Vol. 126, No. 2. (28 July 2006), pp. 248-250.


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In this issue of Cell, Axel and colleagues (Lomvardas et al., 2006) report that a single enhancer of an odorant receptor (OR) gene cluster interacts with multiple OR gene promoters on different chromosomes. This study suggests a mechanism that allows olfactory sensory neurons to choose randomly and express only one out of more than 1000 OR genes.


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