Diffusion weighted imaging in small rodents using clinical MRI scanners

@article{citeulike:2348528, abstract = {Diffusion weighted imaging (DWI) has emerged as a unique and powerful non-invasive magnetic resonance imaging (MRI) technique with a major potential impact on imaging-based diagnosis in a variety of clinical applications including oncology and tissue viability assessment. In light of increasing demand for applying this technique in preclinical investigations using small animals, we have explored the potentials of a clinical magnet for acquiring the DWI in rats and mice with either cerebral ischemia or solid tumors. Through technical adaptation and optimization, we have been able to perform a series of clinically relevant animal studies with conclusions based on DWI quantification. Focusing more on practical aspects and cross-referencing with the current literature, this paper is aimed to summarize our ongoing DWI studies on small rodents with stroke and tumors, and to provide protocols for researchers to replicate similar techniques in their own preclinical and clinical studies.}, author = {Chen, Feng and De Keyzer, Frederik and Wang, Huaijun and Vandecaveye, Vincent and Landuyt, Willy and Bosmans, Hilde and Hermans, Robert and Marchal, Guy and Ni, Yicheng }, booktitle = {Use of Clinical MR Scanners for Small Rodent Imaging}, citeulike-article-id = {2348528}, doi = {http://dx.doi.org/10.1016/j.ymeth.2007.03.007}, journal = {Methods}, keywords = {dw-mri, mri, rodent}, month = {September}, number = {1}, pages = {12--20}, posted-at = {2008-02-07 10:00:11}, priority = {4}, title = {Diffusion weighted imaging in small rodents using clinical MRI scanners}, url = {http://dx.doi.org/10.1016/j.ymeth.2007.03.007}, volume = {43}, year = {2007} }

TY - JOUR ID - citeulike:2348528 L3 - citeulike-article-id:2348528 TI - Diffusion weighted imaging in small rodents using clinical MRI scanners T2 - Use of Clinical MR Scanners for Small Rodent Imaging JF - Methods VL - 43 IS - 1 SP - 12 EP - 20 N2 - Diffusion weighted imaging (DWI) has emerged as a unique and powerful non-invasive magnetic resonance imaging (MRI) technique with a major potential impact on imaging-based diagnosis in a variety of clinical applications including oncology and tissue viability assessment. In light of increasing demand for applying this technique in preclinical investigations using small animals, we have explored the potentials of a clinical magnet for acquiring the DWI in rats and mice with either cerebral ischemia or solid tumors. Through technical adaptation and optimization, we have been able to perform a series of clinically relevant animal studies with conclusions based on DWI quantification. Focusing more on practical aspects and cross-referencing with the current literature, this paper is aimed to summarize our ongoing DWI studies on small rodents with stroke and tumors, and to provide protocols for researchers to replicate similar techniques in their own preclinical and clinical studies. KW - dw-mri KW - mri KW - rodent AU - Chen, Feng AU - De Keyzer, Frederik AU - Wang, Huaijun AU - Vandecaveye, Vincent AU - Landuyt, Willy AU - Bosmans, Hilde AU - Hermans, Robert AU - Marchal, Guy AU - Ni, Yicheng PY - 2007/09// UR - http://dx.doi.org/10.1016/j.ymeth.2007.03.007 ER -