Metabolic Syndrome Is not a Risk Factor for Kidney Dysfunction in Obese Non-diabetic Subjects.

@article{citeulike:2663450, abstract = {Objective:To investigate whether insulin resistance (IR) and the metabolic syndrome (MS) are associated with kidney dysfunction in obese non-diabetic (OND) subjects.Methods and Procedures:Three-hundred and eighty (113M/267F; age = 41 +/- 14 years) OND subjects (BMI >/= 30 kg/m(2); range = 43 +/- 8 kg/m(2)) were studied. Anthropometric measures, blood pressure, fasting glucose, insulin, lipid profile, and serum creatinine were evaluated. Glomerular filtration rate (GFR) was estimated (e-GFR) with the Modification of Diet in Renal Disease equation. Chronic kidney disease (CKD) was defined as e-GFR <60 ml/min/1.73 m(2).Results:e-GFR was associated with gender (being lower in women) (P = 0.001) and age (P < 0.0001). CKD was present in 32 subjects (8.4\%), who were older (P < 0.0001) and more frequently affected by hypertension (P = 0.04) as compared to subjects without CKD. MS was present in 212 (55.8\%) subjects. They were older (P< 0.001), had lower e-GFR (P = 0.02) and were more frequently affected by CKD (odds ratio (OR), 95\% confidence interval (CI) = 2.3, 1.1-5.1) than those without MS. However, differences in e-GFR values and in the risk of CKD were no longer statistically significant after adjusting for age (P = 0.99 for e-GFR and OR, 95\% CI = 1.2, 0.5-2.8 for the risk of CKD, respectively). Homeostasis model assessment of IR (HOMA(IR)) index was neither higher in subject with CKD (P = 0.1) nor inversely correlated with e-GFR (r = 0.1, P = 0.1).Discussion:In OND individuals the risk of CKD is independent of the MS and related abnormalities. This suggests that these individuals are not susceptible to a further deleterious role on kidney function on the top of that played by obesity itself.Obesity (2008) 16 4, 899-901. doi:10.1038/oby.2007.59.}, address = {1Department of Clinical Sciences, Sapienza University, Rome, Italy.}, author = {Gatti, A. and Morini, E. and Cosmo, S. D. and Maiani, F. and Mandosi, E. and Fallarino, M. and Morano, S. and Trischitta, V. }, citeulike-article-id = {2663450}, doi = {10.1038/oby.2007.59}, issn = {1930-7381}, journal = {Obesity (Silver Spring, Md.)}, keywords = {ckd, metabolic, obesity, risk}, month = {April}, number = {4}, pages = {899--901}, posted-at = {2008-04-15 16:11:09}, priority = {2}, title = {Metabolic Syndrome Is not a Risk Factor for Kidney Dysfunction in Obese Non-diabetic Subjects.}, url = {http://dx.doi.org/10.1038/oby.2007.59}, volume = {16}, year = {2008} }

TY - JOUR ID - citeulike:2663450 L3 - citeulike-article-id:2663450 TI - Metabolic Syndrome Is not a Risk Factor for Kidney Dysfunction in Obese Non-diabetic Subjects. JF - Obesity (Silver Spring, Md.) VL - 16 IS - 4 SP - 899 EP - 901 AD - 1Department of Clinical Sciences, Sapienza University, Rome, Italy. SN - 1930-7381 N2 - Objective:To investigate whether insulin resistance (IR) and the metabolic syndrome (MS) are associated with kidney dysfunction in obese non-diabetic (OND) subjects.Methods and Procedures:Three-hundred and eighty (113M/267F; age = 41 +/- 14 years) OND subjects (BMI >/= 30 kg/m(2); range = 43 +/- 8 kg/m(2)) were studied. Anthropometric measures, blood pressure, fasting glucose, insulin, lipid profile, and serum creatinine were evaluated. Glomerular filtration rate (GFR) was estimated (e-GFR) with the Modification of Diet in Renal Disease equation. Chronic kidney disease (CKD) was defined as e-GFR <60 ml/min/1.73 m(2).Results:e-GFR was associated with gender (being lower in women) (P = 0.001) and age (P < 0.0001). CKD was present in 32 subjects (8.4%), who were older (P < 0.0001) and more frequently affected by hypertension (P = 0.04) as compared to subjects without CKD. MS was present in 212 (55.8%) subjects. They were older (P< 0.001), had lower e-GFR (P = 0.02) and were more frequently affected by CKD (odds ratio (OR), 95% confidence interval (CI) = 2.3, 1.1-5.1) than those without MS. However, differences in e-GFR values and in the risk of CKD were no longer statistically significant after adjusting for age (P = 0.99 for e-GFR and OR, 95% CI = 1.2, 0.5-2.8 for the risk of CKD, respectively). Homeostasis model assessment of IR (HOMA(IR)) index was neither higher in subject with CKD (P = 0.1) nor inversely correlated with e-GFR (r = 0.1, P = 0.1).Discussion:In OND individuals the risk of CKD is independent of the MS and related abnormalities. This suggests that these individuals are not susceptible to a further deleterious role on kidney function on the top of that played by obesity itself.Obesity (2008) 16 4, 899-901. doi:10.1038/oby.2007.59. KW - ckd KW - metabolic KW - obesity KW - risk AU - Gatti, A AU - Morini, E AU - Cosmo, SD AU - Maiani, F AU - Mandosi, E AU - Fallarino, M AU - Morano, S AU - Trischitta, V PY - 2008/04// UR - http://dx.doi.org/10.1038/oby.2007.59 ER -